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In this brand-new adventure, Tom and Jerry are left homeless after their families move away without them. Alone in the real world, the two friends get advice from a streetwise dog and his wisecracking friend--who's a flea--then team up with an eight-year-old orphan girl. Now chased by the orphan's evil aunt, alley cats, animal catchers and crazy kidnappers Tom and Jerry use all the lovable tomfoolery they know to rescue their new friend in this madcap adventure.